Health

A healthy life helps prevent fatal prostate cancer in high-risk men

By Robert Preidt HealthDay Reporter

Monday, April 12, 2021 (HealthDay News)

Researchers report that a nutritious diet, regular exercise, and other healthy lifestyle factors may reduce the likelihood of fatal prostate cancer in men at high genetic risk. doing.

“The excessive genetic risk of fatal prostate cancer can be offset by a healthy lifestyle,” concludes co-author Anna Prim. She is a postdoctoral fellow at Brigham and Women’s Hospital in Boston and Harvard University of Public Health.

Genetics accounts for about 58% of changes in prostate cancer risk.

The researchers examined about 10,500 men for whom genetic data were available.

They also identified more than 2,100 prostate cancer cases with a median 18-year follow-up and nearly 240 fatal prostate cancer cases with a median 22-year follow-up. (Median means that half was tracked for a shorter time and half for a longer time.)

In this study, men were grouped into four equal groups. Men in the group with the highest genetic risk are 5.4 times more likely to develop prostate cancer and 3.5 times more likely to develop fatal prostate cancer than men in the group with the lowest genetic risk. It was.

Studies have shown that among men in the high-risk group, men with the healthiest lifestyle are more likely to develop fatal prostate cancer in about half of men with the least healthy habits. ..

High-risk men who had a healthy lifestyle at the start of the study had a 3% lifetime fatal prostate cancer incidence. This is compared to 6% of men at high risk with the least healthy lifestyle and 3% of the entire study population.

The findings were presented at the American Association for Cancer Research (AACR) Virtual Annual Meeting, April 10-15.

“Our findings allow men at high genetic risk to benefit from targeted prostate cancer screening programs aimed at detecting potentially deadly prostate cancer while still curable. We’ll add to the current evidence that it’s sexual, “Plym said in an AACR news release.

A healthy lifestyle was not associated with a reduced risk of developing any type of prostate cancer and did not affect men at low genetic risk for the disease, the researchers emphasized.

Prim said more research is needed to learn why a healthy lifestyle is associated with a lower likelihood of fatal prostate cancer in men at high genetic risk.

One possible explanation: Genetic variants that contribute to increased genetic risk are also most strongly associated with lifestyle.

However, Plym said observational studies do not prove cause and effect, but only a link between lifestyle and risk. Similarly, research presented at conferences is usually considered preliminary until published in a peer-reviewed journal.

For more information

The National Cancer Institute has more information on preventing prostate cancer.

Source: American Association for Cancer Research, News Release, April 10, 2021

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