A key factor in high mortality in women waiting for a liver transplant

Men aged 49 to 63 years were more likely to have chronic hepatitis C and alcoholic liver disease (27% vs. 22, 33% vs. 19%).

“Women waiting for a liver transplant in the United States are about one-third more likely to get sick than men and are more likely to have surgery or die before they receive the liver. I will. “

Women aged 50 to 63 years were more likely to have non-alcoholic fatty liver disease and autoimmune cholestasis liver disease (23% vs 16%, 23% vs 9%).

Researchers led by lead author Jennifer Lai, MD, MBA, General and Transplant Hepatologists at UCSF School of Medicine, have similar liver disease severity in both genders, but have hypertension and coronary artery disease. I found that there are few women.

Nonetheless, tests using the Liver Frailty Index (LFI) have shown that gender-adjusted grip is weak, unbalanced, and slow to get up from a sitting position.

“This is the first time that vulnerability has been identified and quantified as a risk factor among women with cirrhosis who are waiting for a liver transplant,” Lai said.

“The importance of this finding is that this gender difference can potentially be alleviated by basic early interventions such as providing adequate calorie and protein intake and engaging in regular exercise. We can advise women on diet and exercise interventions to build up their diet. ”

The authors said these steps could help women undergoing other organ transplants, as vulnerabilities can play a role there as well. The cause of frailty has not been investigated, but Lai said it was generally due to lack of physical activity, chronic liver failure, and a poor diet.

During the course of the study, women had a 36% increased risk of death from the waiting list. This was defined as death or delisting because the disease was too great to be transplanted.

After adjusting for LFI scores and other variables, researchers concluded that vulnerabilities accounted for 13% of the gender gap in mortality on the waiting list.

Although this study does not address other factors that compensate for gender differences, the authors found that differences in renal function and a high proportion of male donors who may be incompatible with women due to their short stature. I am paying attention to.

According to Lai, the greatest importance of this study lies in the population level of liver transplant patients in the United States.

“Gender mortality on the waiting list has been around for 15 years across the US liver transplant system and will continue if unrecognized,” she said. Fortunately, “I’ve been recognized and I can deal with it.”

Source: Eurekalert

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