In a new study, scientists have come up with plans to deactivate these designer drugs after they have been administered. It provides a potential cure for drug addiction and overdose.
The study was by Ely R, a professor of chemistry at Scripps Research. Callaway, Jr. Was led by Dr. Kim Janda. Janda and his team have developed a vaccine that can counteract the effects of synthetic cannabinoids on rodents and sequestered drug molecules before interacting with the central nervous system. This approach worked in models that simulated vaping and smoking, as drugs are a commonly used method.
Janda said, “Synthetic cannabinoids are far more potent and toxic than users understand well, and their increased prevalence causes serious health problems among young people and adults. We use these drugs. As is often the case, it is an impure form. I hope this will one day help treat cannabinoid use disorders or accelerate the recovery of overdose. “
Not similar to marijuana
Synthetic cannabinoids act on brain cell receptors called THC, similar to marijuana. However, they are made in the laboratory and their structure is not similar to THC. The actual effects of synthetic cannabinoids are unpredictable and can be fatal.
They are often called synthetic marijuana and contain powerful chemicals that can cause serious life-threatening health effects such as nausea, intense agitation, anxiety, vomiting, hallucinations, and seizures.
These drugs are specifically designed to be abused and have not been tested for safety.
Synthetic drugs are often sprayed on dry plant materials to be sold as vapor-breathing liquids, e-cigarettes. Most manufacturers tend to sell their products in colorful foil packages and PET bottles under hundreds of brand names.
According to the Toxicology Control Center, overdose from synthetic cannabinoids is increasing. These synthetic cannabinoids can be mixed with dangerous drugs such as fentanyl, making them more deadly.
Built on previous research
Janda has already developed a vaccine-based approach to treat heroin, fentanyl and cocaine. For this study, Janda and his colleagues studied whether the vaccine was effective against synthetic cannabinoids.
Janda believes it Vaccines for the treatment of addiction are more beneficial than other treatments because they do not require daily pills. It also reduces the risk of overdose if the user recurs.
Vaccines are composed of multiple drug-like antigens that stimulate neutralizing antibodies in the body and can inactivate many types of cannabinoids. Synthetic cannabinoids cover a variety of artificial chemicals.
The team conducted behavioral experiments on mice and found that the vaccine provided protection against psychotropic effects even when the mice were exposed to large doses of the drug. For convenience, the team has also developed an inhalable vaccine formulation.
Janda said, “This study provides a solid foundation for the development of future treatments for synthetic cannabinoid abuse. The ultimate goal is to provide long-term protection for those who may be suffering from substance abuse. is.”