In the event of an error, such as missing a stop sign or emitting a red light while driving, it is important for our survival to be more careful and adapt our actions immediately to prevent further errors. It is important. This ability to adapt behavior after false behavior is one of the key elements of human cognitive control.
‘Important neural pathways to correct behavioral errors associated with many mental disorders. ‘
“Error monitoring and attention deficit deficiencies are common to many psychiatric problems such as schizophrenia, ADHD, and autism spectrum disorders, but for the specific neural pathways that link these processes. Little is known, “said senior author Hirofumi Morishita, MD. , Associate Professor of Psychiatry, Neuroscience, Ophthalmology, and faculty members of the Friedman Brain Institute and Minditch Institute for Pediatric Health Development at Mount Sinai School of Medicine. “Our research was conducted in mice and led by Kevin Norman, a graduate student in our laboratory, to identify linking error monitoring and attention coordination, the two basic components of the human cognitive control system. Represents the first demonstration of the circuit mechanism of. ”
The neural basis of cognitive control is a hotly debated topic in neuroscience, and that parts of the frontal cortex, which are crucial for planning appropriate behavioral responses to external and internal stimuli, are essential for error monitoring. There are many neuroimaging studies that show.
The study of the new Mount Sinai has made its discovery an even more important step. In a series of experiments with mice, enabling the development of a complete suite of neuroscience and technology not possible in humans, researchers have identified specifics derived from the frontal cortex that are involved during important aspects of cognitive control. I found a neural pathway.
Specifically, task-related errors mobilize frontal neurons that project signals into the visual cortex, which processes visual information from the eye, and post-error activation is essential to improve subsequent behavioral performance. I learned something. “Front projection into the visual area is important for attention modulation in visual processing,” explains Dr. Morishita. “In other words, we have shown that direct and specific anterior sensory projections are important pathways for linking past errors to attention-promoting cognitive control mechanisms.” Neural circuits and functional mappings have been enhanced. Not only that, the study of Mount Sinai has the potential to have a significant impact on clinical treatment. The team adopted a technique known as optogenetic stimulation. This is a biological process that employs a combination of genetic and optical techniques to control the activity of individual neurons in order to selectively stimulate the projection of the frontal lobe into the visual cortex. By adopting this technique, researchers were able to improve the attention of these mice when a light pulse was given to them after the error.
The specific cortical pathways identified in this study are modulated using techniques such as transcranial magnetic stimulation and / or transcranial direct current stimulation, and post-error attention adjustment in many of the most common types of psychiatric disorders. There is a possibility that it can be improved.
“On a larger scale, our findings resolve a contradiction between recent studies reporting the mixed contribution of frontal sensory circuits to attentional behavior. This is because this circuit is subject to certain conditions, namely tasks. It suggests that it will only be adopted after related errors, “says Dr. Morishita. “Therefore, we believe that our research will have a wide range of interests and influences in the fields of neuroscience, psychology, psychiatry, and neurology, while providing information on computational models of cognition based on neuroscience.”