Science & Technology

COVID vax protection may be “more unstable” to Omicron mutations

Researchers have compiled a list of mutations in the SARS-CoV-2 peaplomer that may make Omicron variants more resistant to neutralizing antibodies, including those from vaccination.

This may increase the risk of breakthrough cases of COVID-19.

“Since the SARS-CoV-2 virus does not stop mutations, our goal is to provide community resources for the rapid identification, aggregation and sharing of high quality data …”

NS Blog post Gene Godbold, senior scientist at Signature Science LLC, shows nine of the dozens of gene mutations and deletions reported in Omicron variants. spike Researchers suspect that the virus may be helping to evade antibodies.

The data will be submitted as a peer-reviewed publication, but due to the rapid spread of Omicron around the world, the findings will be aggregated while waiting for more data to assess the impact. Sharing is an urgent need, says computer scientists at Rice University. Todd Trengen, The Principal Investigator of the research that embarked Godbold and his company.

Treangen has long focused on solving the computational challenges posed by the current flood of medical data, with a particular focus on pandemic tracking.

According to Godbold, the project has allowed the team to aggregate a wealth of edited data about the virus.

“What we are doing is combining literature citations and sequences to make it easier to interpret new viral variants immediately after they are documented, and the millions of SARS-CoV-2 genomes. It’s about understanding the array, “he says.

“This kind of assessment has spent countless man-years working on the virus to see how mutations work in both laboratory and clinical settings, hundreds of people around the world. I couldn’t try without a researcher, “says Godbold.

Although additional data are needed to assess the severity of COVID-19 cases due to Omicron infection, Godbold said that this variant not only enhances the infectivity of SARS-CoV-2, but also ” vaccination Better than the variants seen before.

“This does not suggest that vaccination is likely to be defeated by the Omicron mutant, and that the protection provided by vaccination is likely to be less stable than the mutant of previous concern. It only suggests, “he writes.

This discovery is part of a project initiated in July with a CDC grant to develop Harvest Variants software for the Treangen Lab for integrated collaborative mutation tracking of SARS-CoV-2. Godbold and Signature Science colleagues have signed a contract to curate a variant of the virus and test third-party software and document services.

Introduced by Treangen in 2014, Harvest software aims to be a suite of open source microbial core / genome alignment and visualization tools that enable real-time monitoring of viral mutations.

According to Treangen, the research team’s goal is to build informatics and computational tools that enable rapid analysis.

“Since the SARS-CoV-2 virus does not stop mutations, our goal is to quickly identify, aggregate, and share high-quality data that complements relevant efforts taking place around the world. Is to provide, “he says.

The Centers for Disease Control and Prevention funded the project.

sauce: Rice University

COVID vax protection may be “more unstable” to Omicron mutations COVID vax protection may be “more unstable” to Omicron mutations

Back to top button