Do Brain Scans Predict the Onset of Alzheimer’s Disease?

Alzheimer’s disease (AD) gradually loses memory and

A few years before the actual symptoms occur.

The research team Algorithm from Brain Scan Data-Amyloid Positron Emission Tomography (PET) Of 236 patients aged 67 years on average. Brain-level measurements of beta-amyloid protein were made using a widely used metric known as the standardized uptake value ratio (SUVR) to scans.

Algorithm and PET scan

“I perform an amyloid PET scan for research studies. When communicating positive results to people with normal dementia, the first question is always” how long does it take to get dementia? ” .. The answer so far has been that “the risk of developing dementia will increase over the next five years.” But what does that mean? Individuals want to know not only if they are at high risk, but also when they may have symptoms. ” According to senior author Susanne Schindler, MD, an assistant professor of neurology.

The purpose of this study is to estimate when a person has no cognitive symptoms but is more likely to develop Alzheimer’s disease. Amyloid PET scans are widely used in the study of Alzheimer’s disease.

However, the current approach is A new way to analyze such scans using a person’s age and data to further point out when symptoms occur.

“If you look at the brains of younger people who have died of Alzheimer’s disease, they usually look pretty healthy except for Alzheimer’s disease. It goes down. Low amyloid intake is enough to cause the disorder. ” Schindler says.

As a result, the study states: There is a turning point in amyloid accumulation, and each individual reaches that turning point at a different age. After this turning point, amyloid accumulation follows a reliable trajectory.

Even those in their 50s and 80s may reach a turning point. However, beyond this turning point, the accumulation of amyloid levels escalate more and more. therefore, Predicting when a turning point will be reached may help further predict the likelihood of developing AD symptoms.

Source: Medindia

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