Science & Technology

Gut bacteria “talk” with horse cells to improve athletic performance

image: A typical Endurance horse (Arabian horse) was presented for a gait test before the start of the race to check the health of the exercise. During the endurance competition (100-160 km), the horses …
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Credit: Eric Barrey

The horse’s gut microbiota communicates with the host by sending chemical signals to the cells. This has the effect of helping the horse expand its energy output. Frontier of molecular biology science.. This exciting discovery paves the way for dietary supplements that can enhance a horse’s athletic performance.

“We were one of the first to show that certain types of horse gut bacteria produce chemical signals that communicate with the intracellular mitochondria of horses that regulate and produce energy,” he said. Eric Barry, author of this study and integrated biology and horse genetics, said. Team leader of the French National Institute for Agricultural and Food Environment. “The biotransformers produced by these bacteria (small molecules produced by breaking down large molecules for food and growth) have the effect of delaying intracellular hypoglycemia and inflammation, which is the movement of horses. I believe it will expand its capabilities. “

Link to illness

Mitochondria, which can be easily described as a cell energy provider, have been shown to be interdependent with gut bacteria in recent studies. In fact, many diseases associated with human mitochondrial dysfunction, such as Parkinson’s disease and Crohn’s disease, have been associated with changes in the gut microbiota in many previous studies.

“Study horses is a good way to assess the relationship between gut microbiota and mitochondria, because the level of exercise that horses perform during endurance races, or mitochondrial function, is similar to that of human marathon runners.” Explains Dr. Nuria. The first author of this treatise, Mach, is also based in the National Institute of Agricultural and Food Environment, France.

She continues. “In this study, at the beginning and end of the Fontainebleau International Endurance Competition, an eight-hour horse race in France, veterinarians were allowed to take blood samples from 20 healthy horses of the same age and performance level. Obtained. These samples provided information on the chemical signals and expression of specific genes, the process by which DNA is transformed into instructions for making proteins and other molecules. Horse intestinal bacterial metabolites. To understand the composition of the race, we first took a stool sample. “

Researchers have found that certain bacteria in the intestine are associated with gene expression by intracellular mitochondria. In addition, the expressed or “turned on” genes were associated with intracellular activity that helped the cell adapt to energy metabolism.

Evolutionary explanation

“Interestingly, mitochondria have a bacterial origin. It is believed that mitochondria formed symbiotic relationships with other components to form the first cells. This is how mitochondria connect with gut bacteria in this way. May explain why you have, “says Barry.

“By gaining a better understanding of the intercommunication between horses and the gut microbiota, Mach can improve individual performance, training methods, and dietary composition intake. Probiotics supplements and pres. Nourishing good bacteria, manipulating the gut microbiota using biotics, may be a way to improve the health and balance of the microbiota and horses and to better maintain endurance exercise. there is.”

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Gut bacteria “talk” with horse cells to improve athletic performance

https://www.eurekalert.org/pub_releases/2021-04/f-gb040121.php Gut bacteria “talk” with horse cells to improve athletic performance

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