Monday, January 4, 2021 (HealthDay News)
People with metabolic syndrome and psoriasis of the skin condition are at particularly high risk of heart attack and stroke, new studies warn.
Psoriasis is known to increase the risk of heart disease, but researchers are now pinning it mainly because of metabolic syndrome.
Metabolic syndrome is a condition that contains all the major risk factors for heart disease, including obesity, diabetes, high cholesterol, and high blood pressure. It is common in psoriasis patients, according to a team at the National Heart, Lung, Blood Institute (NHLBI).
Researchers said new discoveries could lead to new ways to help prevent heart disease in psoriasis patients.
“The metabolic syndrome that is common in our psoriasis patients causes coronary artery disease in this population by increasing the accumulation of plaques that block the arteries of the heart,” said the NHLBI Institute for Inflammatory and Cardiac Metabolism The research author, Dr. Nehal Mehta, who is responsible for this, said.
He said the study showed that two components of metabolic syndrome, hypertension and obesity, contributed most to arterial occlusion plaques and therefore could be good targets for intervention.
Psoriasis not only exacerbates and increases inflammation of blood vessels and the whole body, but also accelerates atherosclerosis.
Mehta and his team collected data on 260 psoriasis patients, including 80 with metabolic syndrome.
Researchers have found that people with both psoriasis and metabolic syndrome have significantly higher inflammation, insulin resistance, and blood cholesterol. Patients with metabolic syndrome were more likely to have plaque buildup in their arteries and were at increased risk of heart attack.
“Even after adjusting for the individual [metabolic syndrome] Factors assessed by waist circumference, blood pressure, and obesity were the most important associations with coronary plaque accumulation, “Mehta said in an NHLBI news release.
Researchers have found that tummy fat is associated with waist size, blood pressure, triglycerides, and high cholesterol.
According to Mehta, this study shows an important link between excess abdominal fat and metabolic syndrome in patients with psoriasis.
Since this was an observational study, it does not prove the cause and effect, Mehta said. However, there is strong evidence that psoriasis patients with metabolic syndrome have high levels of plaque.
The findings were published online on December 28th. Journal of the American Dermatology Society..
For more information
For more information on psoriasis, please visit the US Centers for Disease Control and Prevention.
Source: US National Institute of Cardiopulmonary Blood, News Release, December 28, 2020
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