Inflammatory compounds present in cooked meat associated with childhood wheezing

AGEs are anchored to specific “danger signal” cells in the body, especially abundant in the lungs, which provoke a reaction in the inflammatory immune system. However, it is not clear how they affect the development of respiratory symptoms.

“High consumption of all types of meat more than doubles the chance of sleep interrupted by wheezing and requires medication to relieve symptoms.”

To further investigate this, researchers used responses from the 2003-2006 National Health and Nutrition Examination Survey (NHANES) to influence dietary AGE intake and meat consumption on respiratory symptoms. We investigated the potential impact.

NHANES is a nationally representative annual survey that assesses the health and nutrition of the US population.

The researchers included 4,388 children aged 2 to 17 years who had access to information on dietary patterns and respiratory symptoms assessed by a 139-item food intake frequency questionnaire. The amount of AGEs consumed was calculated from the answers to the Food Frequency Questionnaire.

About 537 (13%) children say they have experienced wheezing in the past year. After considering potentially influential factors such as age, gender, race / ethnicity, household income, body mass index (BMI), and asthma, the higher the AGE score, the higher the odds of wheezing (18%).

It has also been associated with increased odds of sleep disorders due to at least one wheezing (26%), wheezing during exercise (34%), and wheezing requiring medication (35%) over the past year.

Similarly, high intakes of all types of meat more than double the chance of sleep interrupted by wheezing and require medication to relieve symptoms.

Since this is an observational study, the cause cannot be determined. In addition, be aware of researchers as there is no effective way to measure AGE intake. However, they say the findings support the findings of other studies linking pro-inflammatory dietary patterns with wheezing.

“Since some cohort studies have suggested adverse effects of meat consumption on pediatric airway health, a positive correlation between AGE intake and non-seafood meat consumption in our cohort confirms the dietary It reinforces our a priori hypothesis that AGEs may play an important role in the airways. Childhood inflammation. “

Western-style dietary patterns, which feature high-level AGE-rich foods such as meat and saturated fat, promote an inflammatory cascade and may contribute to the development of airway inflammation and asthma, they explain. I have.

In a linked editorial, Professor Jonathan Grig of the Child Health Center at Queen Mary University of London observes that increased evidence contributes to AGEs in the development of asthma.

“There is not enough evidence to recommend changing a child’s meat consumption to reduce asthma, but focusing on the respiratory adverse effects of eating large amounts of cooked meat is broader. It resonates with the agenda, “he suggests.

This includes the 2020 UK Climate Change Health Alliance report. The report concluded that lean meat consumption should be halved if the food system remains within sustainable environmental limits.

“Therefore, it may be time to advocate a diet that includes smaller amounts of higher quality, more sustainable cooked meat, regardless of the adverse health effects of AGEs,” he concludes. I will.

Source: Eurekalert

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