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Key Factors in Lowering Cancer Risk in Obesity

Obese patients can also reduce their risk of cancer after significant long-term weight loss. However, there are relatively few studies on the association between weight loss, cancer risk, and glycemic control in patients with both obesity and type 2 diabetes.

This study published in the journal Diabetes careWe used data from the “SOS” (Swedish obese subject) intervention trial, led and coordinated by the University of Gothenburg, and data from other sources such as the Swedish Cancer Registry.


60% lower risk of cancer

The researchers studied a group of 393 people with type 2 diabetes who underwent obesity surgery and compared it to a control group of 308 people with the same clinical characteristics. That is, they had severe obesity and type 2 diabetes, but had not undergone obesity surgery. In other respects, such as gender composition, blood glucose levels, and smoking, the two groups were comparable.

In the surgery group, 68 (about 17%) developed cancer in parallel with significant weight loss. There were 74 (24%) cases of new cancer in the control group, but these individuals remained severely obese. The median follow-up was 21 years. Overall, the group that underwent obesity surgery had a 37% lower risk of developing cancer.

However, the biggest difference was observed when analyzing cancer risk in patients who achieved normal glucose control and had no recurrence of diabetes for 10 years. Among these patients, the incidence of cancer was 12 of 102 (12 percent) compared to 75 of 335 (22 percent) in the group who had a recurrence of diabetes during the same period. Therefore, the results show that the cancer risk was reduced by 60% in the group where normal glucose control was maintained for 10 years.

Guidance for cancer prevention

“We find that many cancer cases are preventable among patients with type 2 diabetes. These results are an important contribution to a better understanding of the relationship between glucose control and cancer prevention,” said molecular medicine. Says Kajsa Sjöholm, an associate professor of the. Lead author of the study at the Sahlgrenska Academy at Gothenburg University.

Magdalena Tabe, an associate professor of molecular medicine at the Sahlgrenska Academy at Gothenburg University, is the lead author of this study.

“It is estimated that over the next 10 to 15 years, obesity can cause more cancer cases than smoking in some countries. It is clear how serious the condition is. “Shows in,” she says.

“We need a strategy to prevent this progression, and our results can provide important guidance for preventing cancer in patients with obesity and type 2 diabetes,” Taube concludes. increase.

Source: Eurekalert

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