Science & Technology

Next-generation surgical sutures inspired by human tendons can deliver drugs, prevent infections and monitor wounds

Scanning electron microscope image of a cross section of a TGS suture.Credits: Zhenwei Ma, McGill University

Sutures are used to close the wound and speed up the natural healing process, but they can also complicate the problem by damaging the soft tissue with hard fibers. To solve this problem, Montreal researchers have developed an innovative, durable gel-coated (TGS) suture inspired by human tendons.

These next-generation sutures contain a slippery but durable gel envelope that mimics the structure of soft connective tissue. When testing TGS sutures, researchers found that a nearly friction-free gel surface reduced the damage normally caused by conventional sutures.

Traditional sutures have existed for centuries and are used to hold wounds together until the healing process is complete. However, they are far from ideal for tissue repair. Coarse fibers can slice and damage already fragile tissue, causing discomfort and postoperative complications.

According to researchers at McGill University and the INR SÉnergie Matériaux Télé communications Research Center, part of the problem lies in the inconsistency between soft and hard sutures that rub against contact tissue.

Inspired by tendons

To address this issue, the team has developed a new technique that mimics the dynamics of tendons. “Our design is inspired by the human body, the endotenon sheath. The endotenon sheath is tough and durable due to the double network structure. The elastin network strengthens the collagen fibers while binding the collagen fibers. “We do,” said Zhenwei Ma, the lead author and a doctoral student under the supervision of Assistant Professor Jianyu Li of McGill University.

The endotenon sheath not only forms a slippery surface to reduce friction with the tissue around the joint, but also provides the material needed for tissue repair of tendon injuries. Similarly, TGS sutures can be designed to provide personalized medicine based on the needs of the patient, researchers say.

Personalized wound healing

“This technology provides a versatile tool for advanced wound management. We believe it can be used for drug delivery, infection prevention, and even wound monitoring with near-infrared imaging,” said the Department of Mechanical Engineering. Li said.

“The ability to locally monitor wounds and adjust treatment strategies for better healing is an exciting direction to explore,” said Canadian Research Commissioner for Biomaterials and Musculoskeletal Health. One Lee says.

Reference: “Bio-inspired tough gel sheath for robust and versatile surface functionalization” Zhenwei Ma, Zhen Yang, Qiman Gao, Guangyu Bao, Amin Valiei, Fan Yang, Ran Huo, Chen Wang, Guolong Song, Dongling Ma , Zu-Hua Gao, Jianyu Li, April 7, 2021 Science Advances..
DOI: 10.1126 / sciadv.abc3012



Next-generation surgical sutures inspired by human tendons can deliver drugs, prevent infections and monitor wounds

https://scitechdaily.com/next-generation-surgical-sutures-inspired-by-human-tendons-can-deliver-drugs-prevent-infections-and-monitor-wounds/ Next-generation surgical sutures inspired by human tendons can deliver drugs, prevent infections and monitor wounds

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