Pericardial injections that are effective in giving regenerative therapy to the heart

“We wanted a less invasive way to get the drug to the site of injury,” said North Carolina State University / UNC Chapel, a prominent professor of regenerative medicine at North Carolina State University’s School of Molecular Biomedical Medicine. Said Ke Cheng, a professor at North Carolina State University. Hill Joint Biomedical Engineering Department.

“By using the pericardial cavity as a natural” mold “, you can create a heart patch at the site of injury from a hydrogel containing a therapeutic agent. “

In a proof-of-concept study, North Carolina State University and Cheng et al. Of UNC Chapel Hill found two different types of hydrogels (one naturally derived and one synthetic), and two different stem cell-derived therapeutic agents in mice and rats. I examined it with a heart model. attack. The drug was provided via an intrapericardial (iPC) injection.

Through fluorescence imaging, researchers were able to confirm that the hydrogel spreads and forms a cardiac patch in the pericardial cavity. They also found that stem cells or exosome therapeutics were released into the heart muscle, leading to reduced cell death and improved cardiac function compared to the group of animals receiving hydrogel alone without the therapeutic.

The team then turned to a pig model to test the safety and feasibility of the procedure. They performed iPC injections using minimally invasive surgery, which required only two small incisions, and then monitored pig side effects. They did not find any respiratory complications, pericardial inflammation, or changes in blood chemistry until 3 days after the procedure.

“Our hope is that this method of delivering the drug to the heart will be less invasive, less expensive and more therapeutically effective,” says Chen.

“Our early results are promising. This method is safe and has a higher retention rate of the remedy than those currently in use. Then, before starting, the safety of this remedy. And to further test efficacy, additional preclinical studies will be conducted in large animals. Clinical trials. “

“In future clinical settings, we anticipate that iPC injections can be performed with pericardial access similar to the LARIAT procedure, which requires a single small incision in the patient’s chest wall under local anesthesia,” Joe Rossi said. The doctor says. , UNC-Associate Professor of the Department of Cardiology at Chapel Hill and co-author of the treatise.

Source: Eurekalert

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