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Researchers at the Huntsman Cancer Institute reveal insights into how moles turn into melanoma – Scientific Inquirer

Salt Lake City-Mole and melanoma are both skin tumors derived from the same cells called melanocytes. The difference is that moles are usually harmless, but melanoma is cancerous and often fatal without treatment. in the investigation Released today eLife Magazine, Robert Judson-Dr. Torres, Huntsman Cancer Institute (HCI) With researchers University of Utah (U of U) An assistant professor of dermatology and oncology explains how common moles and melanomas form and can turn into melanoma.

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Melanocytes are cells that give color to the skin to protect it from the sun’s rays.Called a specific change to the DNA sequence of melanocytes BRAF Genetic mutations are found in over 75% of moles. The same changes are seen in 50% of melanomas and are more common in cancers such as the colon and lungs.Melanocytes BRAFV600E Mutations stop cell division and result in moles.If there are other mutations in the melanocytes BRAFV600E, They divide out of control and turn into melanoma. This model is called “oncogene-induced aging.”

“Many studies have challenged this model in recent years,” says Judson-Torres. “These studies provided excellent data suggesting that oncogene-induced aging models do not explain mole formation, but all of them lack an alternative that remains elusive. It’s an explanation. “


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With the help of HCI and a collaborator at the University of California, San Francisco, the research team collected moles and melanoma donated by patients and used transcriptmics profiling and digital holographic cytometry. Transcriptomics profiling allows researchers to determine the difference between mole and melanoma molecules. Digital holographic cytometry helps researchers track changes in human cells.

“We have discovered a new molecular mechanism that explains how moles are formed, how melanoma is formed, and why moles sometimes become melanoma,” Judson-. Torres says.

In this study, melanocytes that turn into melanoma do not need to have additional mutations, but are actually affected by environmental signaling when cells receive signals from the skin environment around them that direct them. It shows that. Melanocytes express genes in a variety of environments and direct them to divide uncontrollably or stop dividing altogether.

“The origin of melanoma, which depends on environmental signals, offers new perspectives on prevention and treatment,” says Judson-Torres. “It also plays a role in fighting melanoma by preventing and targeting genetic mutations. It may also be possible to fight melanoma by changing the environment.”

These findings lay the groundwork for studying potential melanoma biomarkers and allow physicians to detect cancerous changes in the blood at an earlier stage. Researchers can also use these data to better understand potential topical agents, reduce the risk of melanoma, delay the onset, or stop recurrence and detect melanoma early. I am interested in.

Image Credit: Huntsman Cancer Institute



Researchers at the Huntsman Cancer Institute reveal insights into how moles turn into melanoma – Scientific Inquirer

https://scientificinquirer.com/2021/11/30/huntsman-cancer-institute-researchers-uncover-insights-into-how-moles-change-into-melanoma/ Researchers at the Huntsman Cancer Institute reveal insights into how moles turn into melanoma – Scientific Inquirer

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