Science & Technology

Researchers use nanoparticles to kill dangerous bacteria hidden in human cells

Macrophages in culture. Credit: Adam Taylor

Researchers at the University of Southampton have worked with colleagues at the Defense Science and Technology Laboratory (Dstl) to develop a new nanoparticle-based technology for killing dangerous bacteria hidden in human cells.

Burkholderia It is a genus of bacteria that causes a fatal disease called melioidosis. The disease kills tens of thousands of people each year, especially in Southeast Asia. Antibiotics given orally or intravenously often do not work well because the bacteria hide and multiply in white blood cells called macrophages.

A new study led by Dr. Nick Evans and Dr. Tracey Newman shows that there are about 1000 small capsules called polymersomes.NS Human Hair Diameter – Can be used to carry antibiotics that kill insects where bacteria grow inside cells.Their findings were published in the journal ACS Nano..

Macrophages are cells of the immune system that have evolved to take up particles from the blood and are essential for their role in preventing infection, but macrophages can be abused by some bacteria that infect and grow inside. It also means that.

In this study, the research team added polymersomes to bacterially infected macrophages. Their results showed that polymersomes were easily taken up by macrophages and associated with intracellular bacteria. This means that it may be an effective way to administer high levels of antibiotics to the site of infection. The team hopes that this will ultimately save patients many lives each year, being treated by injection or inhalation of capsules containing antibiotics.

Eleanor Porges, a PhD student at the University of Southampton School of Medicine and lead author of the study, said: We hope that by doing this, we will be able to reduce the amount of antibiotics used and reuse antibiotics that are not normally considered effective. “

Dr. Nick Evans, an associate professor of biotechnology at the University of Southampton, said: pH scale. Our research has shown that this is not necessary. This makes their use much easier and probably easier to manufacture for clinical use.

“The result of our research was the effort of a true team of people from microbiology, imaging and nanotechnology backgrounds working between Dstl and Southampton. This makes the data very attractive. That’s why I made it. “

The team is currently in the early stages of developing this for clinical application using Dstl, the internal science of defense and security in the United Kingdom.

See also: “Antibiotic loading for intracellular Burkholderia thailandensis clearance” by Eleanor Porges, Dominic Jenner, Adam W. Taylor, James SP Harrison, Antonio De Grazia, Alethia R. Hailes, Kimberley M. Wright, Adam O. Whelan, Isobel. Polymersomes “H. Norville, Joann L. Prior, Sumeet Mahajan, Caroline A. Rowland, Tracey A. Newman, Nicholas D. Evans, November 5, 2021 ACS Nano..
DOI: 10.1021 / acsnano.1c05309

Researchers use nanoparticles to kill dangerous bacteria hidden in human cells Researchers use nanoparticles to kill dangerous bacteria hidden in human cells

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