A project promoted by EMBL Australian researchers at Monash University and Harvard University has found ways to make antibiotics more effective against antibiotic-resistant bacteria (also known as superbags).
According to the World Health Organization, antimicrobial resistance to superbug is evolving and is one of the top 10 global public health threats facing humankind.
This new study provides a way for clinicians to increase the effectiveness of antibiotics without resorting to the dangerous strategy of giving patients high doses or the discovery of new types of antibiotics. ..
During a bacterial infection, the body uses molecules called chemical attractants to mobilize neutrophils to the site of infection.
Neutrophils are immune cells that have the ability to encapsulate and kill dangerous bacteria that are essential to the immune response.
Researchers have made it possible to attach chemical attractants to antibiotics to increase the recruitment of immune cells and improve their killing ability.
The findings are currently published to Nature Communications.
“When we look at how our immune system can fight bacteria, there are two important aspects we see: the ability to trap and kill bacterial cells.
The second is a signal that requires more neutrophils, white blood cells that guide the immune system’s response to resolve the infection, a chemical attractant, “said EMBL Australia and Monash Institute for Biomedical Discovery. Dr. Jennifer Payne, a researcher, said.
Researchers have associated a chemical attractant known as formyl peptide with vancomycin, a commonly used antibiotic that binds to the surface of bacteria, and Staphylococcus aureus, one of the more problematic antibiotic-resistant bacteria. I researched staphylococcal infections.
“We have been working on the use of a dual-function antibiotic-chemical attractant’hybrid’, which improves neutrophil recruitment and increases bacterial involvement and killing,” said Dr. Payne. increase.
“By stimulating such a strong immune system with immunotherapeutic antibiotics, treatment is twice as effective in mouse models as using antibiotics alone at one-fifth lower doses. “, Said Max Cryle, Associate Professor. , EMBL Australia Group Leader, Monash Biomedicine Discovery Institute.
“This highly promising new research tool offers many potential benefits to the ever-increasing threat of drug-resistant superbug,” said Associate Professor Cryle.
Funded by VESKI and the Sister Cities Foundation of Melbourne, the project was funded by taking Dr. Payne from around the world to Boston to study and conduct microfluidic research with Associate Professor Daniel Ilima and Harvard. We collaborated with Dr. Felix Ellet, an expert in this field at the university.
“Microfluidics is a breakthrough for this study because it can generate infected on-chips to monitor the recruitment of human immune cells and observe in real time how immunotherapy enhances the ability to kill MRSA. It was just like what happens in our bodies, “said Dr. Payne.
Partners are urged to continue this study of clinical trials that may develop prophylactic antibiotic strategies in an intensive care environment to protect our most vulnerable people.
This work has resulted in a patent for immunotherapy using an IP owned by Monash University.
Scientists Find Ways to Increase the Effectiveness of Antibiotics to Fight Super Bugs
https://knowridge.com/2021/10/scientists-find-way-to-increase-the-effectiveness-of-antibiotics-to-fight-superbugs/ Scientists Find Ways to Increase the Effectiveness of Antibiotics to Fight Super Bugs