The discovery of new drugs is essential to achieving the eradication of neglected tropical diseases (NTD) in Africa and around the world.Now the researchers PLOS neglected tropical disease We have identified traditional Ghanaian medications that work in the laboratory for three diseases that are specific to Ghana: schistosomiasis, onchocerciasis, lymphatic filariasis.
NTD’s main intervention in Ghana is now high doses of several drugs that are repeatedly recycled, which can lead to reduced efficacy and the emergence of drug resistance. Chronic infections of schistosomiasis, onchocerciasis, and lymphatic filariasis can be fatal.Schistosomiasis is caused by schistosomiasis Schistosomiasis hematobium And Schistosoma mansoni..Onchocerciasis, or river blindness, is caused by parasites Onchocerca volvulus..Lymphatic filariasis, also known as elephantiasis, is caused by parasitic filariasis Wuchereria bancroft..
In the new work, Dorcus Osei Safo of the University of Ghana and colleagues have obtained 15 traditional medicines used in the treatment of NTD in the community from the Association of Traditional Medicine Practitioners in Ghana. The drug was available in aqueous herbal preparations or dry powdered herbs. In all cases, crude extracts were prepared from herbs and screened in the laboratory for their ability to treat a variety of NTDs.
The two extracts, NTD-B4-DCM and NTD-B7-DCM, Schistosoma mansoni It reduces the movement of adult worms and worms by 78.4% and 84.3%, respectively.Another extract, NTD-B2-DCM, was the most active in adults Onchocera onchengi Worms kill 100% of men and over 60% of women. Eight of the 26 crude extracts tested, including NTD-B4-DCM and NTD-B2-DCM, also showed good activity against trypanosoma, a parasite that causes other human diseases. , Was not the original target of traditional medicine.
“By adopting an indigenous knowledge system that has evolved over the centuries, by conducting sound scientific research to produce safe, effective and quality treatments, we have a wealth of undeveloped It has the potential to unleash and shape research, “says the researchers.
Materials provided by PLOS.. Note: The content can be edited in style and length.