Science & Technology

Use of electrical pulses for vaccine efficiency

Figure 1. Design of experiments. (A) Temporary band structure and plasma dynamics of biological solutions during the photoelectric destruction process. (B) Schematic of a photoelectric destruction setup for bubble formation and detection. Red indicates the 1064 nm beam path and cyan indicates the 485 nm probe beam path. Abbreviations refer to Polarizing Beam Splitter Cube (PBS), Beam Splitter (BS), Pulse Energy Meter (EM), Dichroic Beam Splitter (DBS), 750 nm Short Path Filter (SPF), and Photodiode (PD). Numbers 1 and 2 indicate a half-wave plate and a 20 x 0.420 x 0.4 NA microscope objective, respectively. (C) Probit analysis curve and 95% confidence interval for breakdown threshold (

Vladislav Yakovlev, a professor of biomedical engineering at the University of Texas A & M, is part of a multi-university team studying how electrical and optical pulses can help cell absorption of materials, including vaccines.

The team investigated the optical and electrical breakdown of the material. These effects, which explain material changes in the presence of extreme light or electric fields, have been studied since the 1950s. However, the simultaneous application of light and electric fields, especially to biologically related systems, has not been considered so far.

Jakovlev said by investigating the synergies of electricity and electricity Optical pulseResearchers have been able to promote highly localized breakdowns while lowering the threshold for such breakdowns.

The newly discovered synergies are especially important when cell membranes need to be selectively destroyed in a highly localized manner.

Usually, electroporation is a technique of applying an electric field to cells to increase the permeability of cell membranes. Or Ultra short laser pulse It can be used to form small holes in cell membranes. The powerful combination of electroporation and optporation offers the benefits of both approaches, leading to new ways in which drugs and vaccines can be delivered. cell And organization.

“One of the most important effects of this effect, this is General audienceThe accuracy of COVID-19 vaccine delivery has improved, “the team said in an impact statement.

The team recently published a treatise in the journal Photonics research.. The study is funded by the Air Force Science Research Office and is project manager by Sofi Bin-Salamon.

Although this technology is a new addition to the laboratory, the research team said it can be used in a wide range of facilities without the need for sophisticated equipment to produce effects.

“We believe that the unique combination of new basic science and a wide range of influential applications, from extreme light-material interactions to nanotechnology and biotechnology, will be of great interest to a wide audience. “We do,” said Jakovlev.

Diamond color center for nonlinear photonics

For more information:
Zachary N. Coker et al. Synergistic effect of picosecond optical pulse and nanosecond electric pulse on dielectric breakdown in aqueous solution, Photonics research (2021). DOI: 10.1364 / PRJ.411980

Quote: Use of Electric Pulse for Vaccine Efficiency (April 6, 2021) from https: // April 6, 2021 Was acquired by.

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Use of electrical pulses for vaccine efficiency Use of electrical pulses for vaccine efficiency

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